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KMID : 0620920120440050311
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Experimental & Molecular Medicine
2012 Volume.44 No. 5 p.311 ~ p.318
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Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation
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Jung In-Hyuk
Lee You-Han
Yoo Ji-Young
Jeong Se-Jin
Sonn Seong-Keun
Park Jong-Gil
Ryu Keun-Ho
Lee Bong-Yong
Han Hye-Young
Lee So-Young
Kim Dae-Yong
Lee Hang
Oh Goo-Taeg
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Abstract
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In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis.
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KEYWORD
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atherosclerosis, cilostazol, cytokines, disease models, animal, Ginkgo biloba , inflammation, macrophages, reactive oxygen species
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